Prof. E. Dilip de Silva
Senior Professor of Organic Chemistry
Department of Chemistry,
University of Colombo,
Work Phone: (9411) 2503 367
Work Fax: (9411) 2503 367
Selected Research Publications
- “Manoalide, An Antibiotic Sesterterpenoid from the Marine Sponge Luffariella variabilis (Polejaffe)”, E.D. de Silva and P.J. Scheuer, Tetrahedron Lett. 1980, 21, 1611 – 1614
- “Chromodoralide A, A Rearranged Diterpene with a New Carbon Skeleton from an Indian Ocean Chromodoridae”, E.J. Dumdei, E.D. de Silva, R.J. Anedrsen, M.I. Choudhary and J. Clardy, J. Am. Chem. Soc. 1989, 111, 2712 – 2713
- “Geodiamolides C to F, New Cytotoxic Cyclodepsipeptides from the Marine Sponge Pseudaxina sp.” E.D. de Silva, R.J. Andersen and T.M. Allen, Tetrahedron Lett. 1990, 31, 489 – 492
- “Motuporin, A Potent Protein Phosphatase Inhibitor Isolated from the Papua New Guinea Sponge Theonella swinhoei Gray,” E.D. de Silva, D.E. Williams, R.J. Andersen, Heide Klixe, C.F.B. Holmes and T.M. Allen, Tetrahedron Lett. 1992,33, 1561 – 1564
- “Cytotoxic Peptides from the Marine Sponge Cymbastela sp.,” J.E. Coleman, E.D. de Silva, F. Kong, R.J. Andersen and T.M. Allen, Tetrahedron 1995, 51 (39), 10653 – 10662
- “Ambewalamides A and B, Antineoplastic Epidithiapiperazinediones Isolated from the Lichen Usnea sp.,” D.E. Williams, K. Bombuwala, E. Lobkovsky, E.D. de Silva, V. Karunaratne, T. Allen, J. Clardy and R.J. Andersen, Tetrahedron Lett. 1998, 39, 9579 – 9582
- “Papuamides A – D, HIV-Inhibitory and Cytotoxic Depsipeptides from the Sponge Theonella mirabilis and Theonella swinhoei Collected in Papua New Guinea,” P.W. Ford, K.R. Gustafson, T.C. McKee, N. Shigematsu, L.K. Maurizi, L.K. Pannell, D.E. Williams, E.D. de Silva, P. Lassota, T.M. Allen, R. Van Soest, R.J. Andersen and M. R. Boyd, J. Am. Chem. Soc. 1999, 121, 5899 – 5909
- “Synthetic Transformations of the Eleutherobin Reveal New Features of its Microtubule-Stabilizing Phamacophore,” R. Britton, E. D. de Silva, C. M. Bigg, L. M. McHardy, M. Roberge and R. J. Andersen, J. Am. Chem Soc. 2001, 123, 8632-8633
- “Anticancer Agents from Unique Product Sources,” Chris M. Ireland , William Aalbersberg, Raymond J. Andersen , Semiramis Ayral-Kaloustian , Roberto G.S. Berlinck , Valerie Bernan , Guy Carter , Alice C.L. Churchill , Jon Clardy , Gisela P. Concepcion , Dilip E. De Silva , Carolyn Discafani, Tito Fojo , Philip Frost , Donna Gibson , Lee M. Greenberger , Michael Greenstein , Mary Kay Harper, Robert Mallon , Frank Loganzo , Maria Nunes , Marianne S. Poruchynsky , Arie Zask, Pharmaceutical Biology 2003, 41 (supplement I) 15 – 38
- .“Oppositines A and B, Sesquiterpene Pyridine Alkaloids from a Sri Lankan Pleurostylia opposite,” E.L. Whitson, S.M.V. Damayanthi Mala, C.A. Veltri, T. S. Bugni, E.D. de Silva and C.M. Ireland, J. Nat. Prod. 2006, 69, 1833 – 1835
- “Isolation of 2-Pyridone Alkaloids from a New Zealand Marine-Derived Penicillium species,” E.D. de Silva, A. Geiermann, M.I. Mitova, P. Kuegler, J.W. Blunt, A.L.J. Cole and M.H.G. Munro, J. Nat. Prod. 2009, 72, 477 – 479.
- “Dhilirolides A – D, Meroterpenoids Produced in Culture by the Fruit-infecting Fungus Penicillium purpurogenum Collected in Sri Lanka,” E.D. de Silva, D.E. Williams, D.R. Jayanetti, R.M. Centiko, B.O. Patrick, R.L.C., Wijesundera and R.J. Andersen, Organic Letters, 2011, 13 (5), 1174 – 1177.
Honours & Awards:
- Open Grants Scholarship, East West Center, Honolulu, Hawaii 1977 – 1979.
- Department Research fellow, Department of Chemistry, University of Hawaii at Manoa, 1979 – 1980(Awarded for excellence in research).
- Outstanding Teaching Assistant, Department of Chemistry, University of Hawaii at Manoa 1979 – 1980.
- Natural Resources Energy and Science Authority of Sri Lanka – Merit Award for Scientific Research in Chemical Sciences – 1986, Awarded for “Chemical Investigation of Sri Lanka Soft Corals”.
- Sri Lanka Association for the Advancement of Science – General Research Committee Award – 1995 Awarded for an outstanding contribution to Sri Lankan Science.
- Professor PPGL Siriwardene Memorial Oration Gold Medal award, Awarded by the Institute of Chemistry, Ceylon, 15th May 2007.
Research Group Website Academic Record:
- Ph.D. Hawaii, USA.
- B.Sc. (Special in Chemistry) , University of Colombo, Sri Lanka.
- Oceans represent a vast and largely unexplored resource for the discovery of novel secondary metabolites with useful biological activities in the treatment of human diseases. Our research has mainly focused on marine invertebrates, mainly sponges and mollusks, as a source of biologically active compounds with novel structural features. In the bioassay-guided isolation of active compounds, we have employed a range of tests from simple anti-bacterial paper-disc assays to anticancer assays done in collaboration with Professor Raymond Andersen of the University of British Columbia, Canada. The structure elucidation of the active compounds, heavily depend on 2D-NMR spectroscopy.